One of the most successful performance teams in all of Christian music, Bill & Gloria Gaither first teamed up professionally in the renowned gospel music act the Gaither Trio (she replaced his sister Mary Ann). The trio was inducted into the Gospel Music Association Hall of Fame in 1999.

In addition to recording with the trio, Bill and Gloria recorded as a duo and as part of the Gaither Vocal Band. Bill has been an extremely prolific composer of new gospel material, publishing more than 500 songs, including many that have become contemporary standards in the genre. Bill's popular television program, The Gaither Gospel Hour, and a series of videos documenting many of the legends of Southern gospel led to a creative rebirth of what had been a declining genre of music. In all, they have recorded dozens of albums, won multiple Grammy Awards and numerous Dove Awards, and Bill has been the Gospel Music Association's songwriter of the year many times. The couple continue to live just miles from the farm in Alexandria, Indiana, where Bill was born and raised.